Clooney said a auto turned in front of him and he hit it head-on, smashing the windshield, CNN reported.
According to local publication La Nuova, the driver of the auto stayed to help Clooney while they waited for the ambulance - can you imagine realizing that you just hit George Clooney with your vehicle?
Italian news agency ANSA and local newspapers report the star was taken by ambulance to the A&E of the John Paul II hospital in Olbia.
A hospital official confirmed to NBC that his injuries were not very bad, so the 57-year-old got discharged pretty fast.More news: US threatened nations over breastfeeding resolution
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Clooney is a Northern Kentucky native.
"George was treated and released from an Olbia hospital", Clooney's rep said in a statement. "He is recovering at home and will be fine", a source told the Daily Mail. He has already been released from the hospital at this time.
Clooney was in Sardinia shooting his Hulu limited series Catch-22. According to Carabinieri officer Alberto Cicognani, the driver of the Mercedes hit Clooney after failing to stop at a turn.
The north-east coast of Sardinia is popular with the rich and famous, although Clooney is on location on the island to film a new mini-series, Catch 22.
Pictures from George Clooney's motorcycle crash have emerged, showing the dramatic scene in Sardinia. Recent reports had stated that the two have been joined by the actor's parents as well.