Samantha Markle suffered the injuries on Wednesday (16May18) during a confrontation with the paparazzi in Florida. Mark reportedly swerved to the left while trying to avoid him, running into a concrete barrier.
He says Samantha, who has MS, was unable to lift herself up and her foot was twisted backward.
Samantha has claimed she only lost contact with Meghan previous year.
The paparazzo fled the scene, and E.R. doctors are now treating Samantha.
She suffered an apparent broken ankle and fractured knee.
Mum Doria, who was yesterday pictured heading to the airport to make her way to the United Kingdom for her daughter's big day, is now tipped to give Meghan away after Thomas said he had to miss the wedding on Saturday and undergo a heart operation.More news: Ireland's Test cricket debut falls short as nervy Pakistan claim victory
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Markle's father already announced that he will not be attending the royal wedding following his controversial staged photos.
Samantha then came forward to say the pictures had been her idea, as she wanted to show her father in a good light and counter previously unflattering paparazzi images.
The news follows yesterday's "will he-won't he" saga where Meghan's father Thomas Markle went back and forth on walking his daughter down the aisle on Saturday. "I really think that they have taken advantage of the situation and have embarrassed Meghan", she said.
She said on ITV's Loose Women on Monday: "I have to say, I'm not taking it personally".
"And how do you defend yourself when there's no evidence, there's nothing beyond the created social label that creates the public emotional swell and when it gets that big it's overwhelming", Samantha added.
She is reportedly writing a book called "The Diary of Princess Pushy's Sister". "You have been trashing her for two years, you little vulture!"