Guardiola's side swept aside nearly all the teams stacked before them during this season's record-breaking title-winning campaign, but the Reds have beaten them in recent meetings.
But beyond City's impressive numbers, Guardiola takes the most pride from the irresistible style in which his team have racked up their achievements.
"It's incredible, I don't have words, 100 points!"
"But for me the Champions League is without doubt a very special competition for us and it is my dream to win it in a Manchester City shirt".
The Argentine is yet to win a trophy as coach and question marks remain over how long the extremely talented young core of the Tottenham team will stay together whilst earning significantly less than their rivals in the top six.
Record-breaking City end season on a high Rarely has City boss Pep Guardiola celebrated a goal like he did when Jesus' exquisite 93rd-minute chipped finish hit the net.
As the graphic shows, this season, Man City accumulated the most points, have won the most games, including away victories and consecutive wins, scored the most goals, have greatest goal difference, and even made a points gap to 2 place. Wow.More news: Homeland chief berated, seen as close to quitting
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"Numbers are numbers, they are the effect of the way we played".
"The important thing is in the games we tried, we tried, we tried", Guardiola added.
"We were better than our opponents and the records we broke came from the way we played". Swansea, Stoke and West Brom drop to the Championship while Wolves and Cardiff will be back in the Premier League.
But they had no intention of letting the impending party distract them on the south-coast.
Guardiola was clearly intent on victory and, after an attacking substitution which saw forward Jesus replace left-back Fabian Delph, Sterling struck the right post with a deflected effort before John Stones' header from the resultant corner was tipped over by Alex McCarthy.
Swansea manager Carlos Carvahal and players wear a dejected look after their relegation from the Premier League.
Extending that form out over the course of 38 games is now the challenge for the German to deliver a first league title since 1990.