Pep Guardiola's side won the league with five games to spare, but in a manner most unexpected after a slip-up by their city rivals.
Former Manchester United defender Jonny Evans is also a major doubt for the contest with a knee problem. Jose Mourinho should have a full squad to pick from other than that, as Daley Blind, Phil Jones, Marcos Rojo and Marouane Fellaini have all recently returned from various injury issues.
It is City's fifth English top-flight title, their last Premier League triumph having come in the 2013-14 season.
Thierry Henry: "I am not surprised with what Pep has done in this league and a year ago, I was one of the people saying stop having a go at the man because that's how he plays". On the right-side of the back four, Antonio Valencia is expected to start with veteran Ashley Young set to occupy the opposite side. "When the burden and standard of proof is applied, we could not properly say we were satisfied that the player probably spoke the offending words".
Fast-forward to Sunday April 15, 2018 and Guardiola's City side has achieved a domestic double, adding the Premier League to the League Cup they won in February. In fact, the Baggies could be relegated this weekend itself, if they lose at the Old Trafford and results elsewhere go against them.
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Premier League - Follow the Football match between Manchester United and West Bromwich Albion live with Eurosport.
In the United States, the game will be shown on NBCSN at 11:00 AM ET.
While they missed out narrowly on that particular record, here are some of the best Opta numbers from City's special Premier League season.
Manchester United have kept a league-high 16 clean sheets this season, with 11 of those coming at Old Trafford - also the most in the league. With the manager unable to get any kind of momentum going with his side, it is hard to imagine another 2005 situation when the Midlands club managed arguably the greatest escape from the drop in a Premier League season.
But by season's end, City's title will be no less satisfactory.
"I'm sure the atmosphere will be very positive, so we must take the opportunity to put on a good game and a win for our fans". But what was different was that West Brom got legit chances on goal all game and picked their moment to make United pay.