The maximum-security facility that houses about 1,500 inmates in Bishopville, about 55 miles from Columbia, is home to some of South Carolina's most violent, longest-serving offenders.
Just before midnight, police services from the corrections department joined SLED agents to gain control of the "ongoing situation" at the prison in Bishopville.
Hours of fighting among inmates inside a maximum security facility in SC has led to the deaths of seven prisoners and injuries of 17 others, state corrections officials said early Monday.
The SCDC says no staff members or officers were injured.
State officials have pledged for years to make South Carolina's prisons, particularly Lee Correctional Institution, safer after a series of deadly fights.More news: Two-Day-Old Girl Flushed Down Toilet in Kerala Clinic
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The Lee County Fire Department tweeted out photos of multiple crews at Lee Correctional.
At least seven inmates are dead following a major incident at a prison in SC.
Last month, inmates in one part of the prison allegedly took an officer hostage and controlled one side of a dormitory, part of a troubled history that has saw one inmate kill another in February and two officers stabbed in 2015.
This is a developing story and will be updated as more information becomes available.