Tsvangirai had been in and out of hospital since disclosing in June 2016 that he had colon cancer.
NASA head Raila Odinga has expressed sorrow at the passing on of Zimbabwe opposition leader Morgan Tsvangirai.
His career was marked by a long political struggle against former President Robert Mugabe and he had been beaten and imprisoned numerous times.
Tsvangirai, 65, was leader of the Movement for Democratic Change (MDC).
In 2009 he went into a power-sharing government with Mugabe, serving as prime minister until elections in 2013.More news: Proposal to replace SNAP with food delivery program causes concern
More news: Likud, Netanyahu Supporters Say Prime Minister Will Survive
More news: England to scrummage with Georgia in Six Nations rest week
Tsvangirai's legacy is in safe hands at all party levels. Some in his own party accused him of an autocratic leadership style, particularly in 2005 when they said he overrode a party decision to participate in the 2005 Senate elections. In a tense climate, Tsvangirai failed to raise his concerns over election irregularities to sympathetic observers until it was too late.
To honour his unfailing dedication to Zimbabwe's movement to free its people from a dictatorship, The Citizen has chosen three quotes from Tsvangirai that will stay with us forever, and inspire future politicians in the region.
Waxaa caawa fiidkii Isbitaal ku yaalla magaalada Johannesburg ee dalka South Africa ku geeriyooday hogaamiyihii mucaaradka wadanka Zimbabwe, Morgan Tsvangirai. While Tsvangirai led the presidential ballot, he failed to garner the 50 percent plus one vote needed to avoid a run-off.
But his health deteriorated rapidly over the past several months, and after successive temporary leaves of absence, his party was dogged by deadly infighting. As his health worsened, Tsvangirai's party was already facing a succession battle.
"Until his death Dr Tsvangirai remained a source of inspiration to a generation of leaders across the Continent for his courage and determination in the face of monumental odds", said the Orange party leader.