Despite rumours of a rift between the couple, Lisa responded to questions about the status of the couples marriage by tweeting that she hadn't been out to Australia with Ant for 10 years.
The couple met at a roadshow in Newcastle in the mid-1990s while Lisa was an aspiring pop star in a group called Deuce, who enjoyed a couple of chat hits before breaking up.
Both Ant and Lisa have asked for respect and privacy during this harrowing time.
She liked a fan-made montage of their relationship and later shut down reports that labelled her Ant's "enstranged" wife.
A source added: "This was a tough decision for Ant but he has to do the right thing for his health".
No further comment on the situation is expected to be made.
Showing her support for her son during the hard period, Ant's mum Christine brought along her pooch, and chatted to her son as they walked along.More news: Vikings Fans Gear Up For 1st Playoff Game At US Bank Stadium
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It follows his stint in rehab earlier this year for an addiction to prescription drugs, following a botched knee operation.
And Lisa has even taken the time to like some of the most touching messages she has received.
It wasn't until 12 years later that the smitten couple finally Wednesday at a church in Taplow, Buckinghamshire in front of 150 friends and family.
Ant and Dec and their wives Lisa Armstrong and Ali Astall arrive at Buckingham Palace, where the pair were awarded OBEs by the Prince of Wales at an Investiture ceremony on January 2017 in London.
He told the Sun: "I've put Lisa through hell with mood swings and depression and how it affects you".
Ant had initially hidden his addictions from Lisa and his best friend and presenting partner Declan Donnelly.
After a lengthy romance Ant proposed to her whilst on holiday in Dubai on April 26, 2005. She's constantly working - sometimes more than me!' 'If we're blessed with children, then we'd be over the moon!'