Guice was expected to forgo his season season and he announced his decision via Twitter.
Guice got off to a quick start this past season, topping the 100-yard mark in each of the first two games and combining for four touchdowns.
LSU running back Derrius Guice made it official Wednesday: He is heading to the NFL. Other backs who have declared for the draft include Penn State's Saquon Barkley (who is projected to be the first back taken), Stanford's Bryce Love, USC's Ronald Jones, Auburn's Kerryon Johnson and Georgia's Nick Chubb.More news: Red Fort terror attack suspect sent to 10-day police custody
More news: Billionaire Peter Thiel Buys $20M Worth of Cryptos, Compares Bitcoin To 'Gold'
More news: Now you can drive a vehicle with your brain using Nissan's technology
Guice, 5-11, clocked out of the 2017 season with 1,251 yards on 237 carries and 11 touchdowns.
"Having the opportunity to play for this storied university was truly an honor", Guice said in his video. Guice is a Baton Rouge native. He finished with 2,638 yards and 26 rushing touchdowns over his final two seasons in Baton Rouge. Guice (5'11/216) took his sweet time weighing his options, but as expected, he's chose to throw his hat into the draft ring.
With his departure for the draft, Guice ends his LSU career with 3,074 yards, which leaves him fifth on LSU's all-time rushing list behind Faulk, Dalton Hilliard, Charles Alexander and Fournette. He has three of the top four single-game performances in school history, including a school-record 285-yard performance against Texas A&M in the 2016 regular-season finale.