He said: "That snake could pretty much kill any full-grown man".
The python, which weighs 132 pounds, was caught by hunters Friday night at the Big Cypress National Preserve.
"Got her out, shot her right in the head while I was holding her", Leon said Monday in a video released by the South Florida Water Management District.
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Leon also holds the state record for the biggest ever python kill. The invasive species is devastating wildlife with its uncontrollable appetite.
The snakes were captured on state land in Miami-Dade, Broward and Collier counties.
Leon and two other hunters will bring in $375 for the massive reptile captured Friday.
The snakes first started appearing in the area in the 1980s, and are now considered to be the top predator, outranking alligators.
Since the program's initiation in March, more than 730 pythons have been removed from the Everglades. The Miami Herald reports the snakes are in part to blame for diminishing the population of small mammals, including marsh rabbits and raccoons.