Despite the USA vote, the resolution condemning the ongoing economic embargo on Cuba passed overwhelmingly in the U.N. General Assembly, 191-2.
U.S. Ambassador Nikki Haley said before the vote that the U.S. will vote against the embargo resolution "as long as the Cuban people continue to be deprived of their human rights and fundamental freedoms".
Before casting the no vote on Wednesday, Haley also said that the USA would continue to oppose the resolution "as long as the Cuban people continue to be deprived of their human rights and fundamental freedoms", according to The Associated Press.
Last October, then-President Barack Obama's administration abstained for the first time in 25 years on the embargo resolution as the USA leader and Cuban President Raul Castro moved forward with the historic warming of relations between the two countries.
"The United States opposes this resolution today in continued solidarity with the Cuban people and in the hope that they will one day be free to choose their own destiny", she said.
The Trump administration will defend America's decades-old economic embargo on Cuba in a United Nations vote this week, the State Department said Tuesday, in a reversal from the Obama administration that reflects deteriorating U.S.
But ties have markedly worsened since President Donald Trump assumed office, notably over a series of mysterious sonic attacks that have targeted US personnel in Cuba.More news: NYC Terror Victims: Tourists From Argentina & Belgium Among 8 Slain
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"Today, I say that Cuba will never agree to conditions or anything being imposed on this order", Rodriguez said.
USA officials say 21 embassy employees were deliberately targeted.
Cuba has denied involvement in the attacks.
General Assembly resolutions are nonbinding and unenforceable.
Before 2016, the yearly vote had pitted the United States and dwindling number of allies against the rest of the world.
HaleyUN: Assad government responsible for April sarin gas attack Haley escorted from refugee camp amid protest United States officials to recommend Tillerson label Rohingya violence "ethnic cleansing" MORE marked an about-face from a year before, when the USA abstained from a vote for the first time in 25 years.