Nacho Monreal is expected to be available, but Laurent Koscielny has been nursing a troublesome Achilles which flared up before the worldwide break, while Calum Chambers is recovering from a groin problem.
Nevertheless, Arsene Wenger is ready to call upon the Frenchman for this weekend's visit to Watford with Mustafi certain to miss out.
"Koscielny has a definite final test tomorrow. But he trained on his own and the first signs are positive so we made a decision to give him a test tomorrow".
"Watford are a strong side, well balanced and a tough opposition for everybody". I think about sorting out the problem, but overall I will decide completely tomorrow the line-up because Koscielny will have a test.More news: McConnell promises to speed pace on judicial nominees
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He added: 'The player I expected to lose the least during the break was Mustafi.
It was in Belarus where Wilshere showed shades of the form that saw him regarded as one of England's brightest young players when he first broke through at The Emirates.
"I didn't expect him to play and Germany had already qualified so their matches would have been less intense".
Koscielny has had the problem for many seasons and though he has not yet resumed full training, he is set to return to action with the squad ahead of Saturday's game.
Alexis Sanchez will not report back from global duty with Chile until Friday, but Wenger has no concerns over the forward or Aaron Ramsey's mental state after their World Cup exits.